Which of the following conditions show dominant pattern of inheritance?

A. Huntington disease

B. Wilson’s disease

C. Polycystic kidney disease

D. Fragile X syndrome

E. Duchenne muscular dystrophy

Answer

A. True – Huntington disease is a autosomal dominant condition.

B. False – Wilson’s disease is an autosomal recessive condition, so as Hereditary Hemochromatosis.

C. True – Polycystic kidney disease (PKD) can be inherited as autosomal dominant (majority) and autosomal recessive (minority). So, there are two types of PKD. Those are autosomal dominant PKD (ADPKD) and autosomal recessive PKD (ADPKD).

D. True – Fragile X syndrome shows X-linked recessive inheritance.

E. False – Duchenne muscular dystrophy shows X-linked recessive inheritance, as does Becker’s muscular dystrophy.

Note

Autosomal dominant disorders

• Achondroplasia
• Antithrombin III deficiency
• Ehlers-Danlos syndrome
• Gilbert’s disease
• Hereditary haemorrhagic telangiectasia
• Hereditary elliptosis, hereditary spherocytosis
• Huntington’s disease
• Marfan’s syndrome
• Neurofibromatosis
• Polycystic kidney disease (adult)
• Protein C deficiency
• Osteogenesis imperfecta
• Treacher Collins syndrome
• Tuberous sclerosis
• Von Willebrand’s disease

X-linked dominant disorders

• Vitamin D resistant rickets
• Rett’s syndrome
• Fragile X syndrome